Turns out C-b is quite useful for navigation in vim and other programs. Also, the C-space issue seems to only happen when using Alacritty and WSL, so I'll just avoid this combination for now.
The default escape-time of 500ms made it very annoying to use vim inside of tmux and 50ms seems to make vim responsive enough.
This is easy to type on the Moonlander and prevents issues on Windows with WSL, where C-space was being eaten by the console emulator.